海外医薬品不足情報｜医薬政策企画 P-Cubed

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諸外国不足状況

2025.04.01 [ 英国 ]
英国NICE医薬品情報サービス　Megestrol (Megace) 160mg tablets
Medicine supply notification: Megestrol (Megace) 160mg tablets
2025年4月中旬まで在庫切れ。メドロキシプロゲステロンMedroxyprogesterone (Provera)200mgと400mgの錠剤は引き続き利用可能で、需要の増加を支えることができ、ジェネリック版は4月に発売される予定。

2025.03.30 [ フランス ]

ANSMフランス供給不足情報（2025年3月24日～3月30日）

Ingredients	Status	Update	Specialty
rifamycin sodium	Out of stock	28/03/2025	Rifamycin Chibret 1000,000 IU per cent, eye drops solution –
carmustine	Out of stock	28/03/2025	Gliadel 7.7 mg, implant –
clopidogrel (clopidogrel hydrogen sulfate)	Supply tension	27/03/2025	Clopidogrel 75 mg, film-coated tablet –
triclabendazole	Supply tension	27/03/2025	Egaten 250 mg, scored tablet –
pancreas powder	Available again	27/03/2025	Eurobiol 25 000 U, gastro-resistant capsule –
pancreas powder	Availability	27/03/2025	Eurobiol 12 500 U, gastroresistant capsule –
oseltamivir	Availability	27/03/2025	Ebilfumin 75 mg, capsule –
tetracosactide	Available again	27/03/2025	Synacthen 0.25 mg/1 ml, solution for injection –
peginterferon alfa-2a	Supply tension	26/03/2025	Pegasys 90 micrograms, 135 micrograms and 180 micrograms solution for injection in pre-filled syringe –
cyamemazine	Out of stock	26/03/2025	Tercian 50 mg/5 ml, solution for injection in ampoule –
methylphenidate (hydrochloride)	Remise à disposition	26/03/2025	Medikinet 30 mg, modified-release capsule –
oseltamivir	Available again	25/03/2025	Tamiflu 75 mg, capsule –
furosemide	Supply tension	24/03/2025	Furosemide Teva 500 mg, scored tablet –
apraclonidine (apraclonidine hydrochloride)	Remise à disposition	24/03/2025	Iopidine 0.5%, eye drops solution –

2025.03.30 [ ドイツ ]

BfArMボトルネック・レポート（2025年3月24日～3月30日）

Active ingredients

Type of reason

Message type

Date of the last message

Atorvastatin calcium trihydrate (Ph.Eur.)

Other

Initial notification

28.03.2025

Vibegron

Production problem

Initial notification

28.03.2025

Fosfomycin sodium (Ph.Eur.)

Production problem

Change notification

28.03.2025

Sodium (methylprednisolone-21-succinate)

Other

Initial notification

28.03.2025

Atomoxetine hydrochloride

Production problem

Change notification

27.03.2025

Galantamine hydrobromide

Production problem

Change notification

27.03.2025

Moxifloxacin hydrochloride (Ph.Eur.) ((with details of water content (1:x)))

Production problem

Change notification

27.03.2025

Urapidil

Other

Change notification

27.03.2025

Duloxetine hydrochloride

Other

Initial notification

27.03.2025

Salbutamol sulfate

Other

Change notification

27.03.2025

Tranexamic acid

Other

Change notification

27.03.2025

Selegiline hydrochloride

Other

Change notification

26.03.2025

Amoxicillin trihydrate

Other

Change notification

26.03.2025

Quetiapine fumarate (Ph.Eur.)

Other

Change notification

26.03.2025

Fusidic acid (Ph.Eur.)

Other

Initial notification

26.03.2025

Mometasone furoate (Ph.Eur.)

Other

Initial notification

26.03.2025

Hydrocortisone

Other

Change notification

26.03.2025

Azithromycin monohydrate

Other

Initial notification

25.03.2025

Tacrolimus monohydrate

Other

Initial notification

25.03.2025

Sodium valproate

Other

Initial notification

25.03.2025

Tamoxifen citrate

Other

Change notification

25.03.2025

Methylphenidate hydrochloride

Other

Initial notification

25.03.2025

Carbamazepine

Other

Change notification

25.03.2025

Methylphenidate hydrochloride

Other

Initial notification

25.03.2025

Primidone

Other

Change notification

25.03.2025

Buprenorphine

Other

Change notification

25.03.2025

Quetiapine fumarate (Ph.Eur.)

Other

Change notification

25.03.2025

Buprenorphine

Other

Change notification

25.03.2025

Azithromycin dihydrate

Other

Change notification

25.03.2025

Ampicillin sodium

Production problem

Initial notification

24.03.2025

Cafedrine hydrochloride; theodrenaline hydrochloride

Production problem

Change notification

24.03.2025

Dexamethasone dihydrogen phosphate disodium (Ph.Eur.); gentamicin sulphate

Production problem

Initial notification

24.03.2025

Salbutamol sulfate

Other

Initial notification

24.03.2025

Hydrocortisone

Other

Change notification

24.03.2025

2025.03.30 [ オーストラリア ]

TGAオーストラリア供給不足情報（2025年3月24日～3月30日）

Active ingredients	Dosage form	Quantity of active ingredients	Shortage status	Availability	Reason	Last updated
fenofibrate	Tablet, film coated	145 mg	Current	Limited Availability	Manufacturing	28/03/2025
ciprofloxacin hydrochloride	Tablet, film coated	277.5 mg	Current	Limited Availability	Manufacturing	28/03/2025
risperidone	Tablet, film coated	3 mg	Current	Unavailable	Manufacturing	28/03/2025
levetiracetam	Tablet, film coated	1000 mg	Current	Limited Availability	Transport / Logistic issues / Storage capacity issues	28/03/2025
galantamine hydrobromide	Capsule, modified release	10.252 mg	Current	Unavailable	Manufacturing	28/03/2025
galantamine hydrobromide	Capsule, modified release	10.252 mg	Current	Unavailable	Manufacturing	28/03/2025
galantamine hydrobromide	Capsule, modified release	20.504 mg	Current	Unavailable	Manufacturing	28/03/2025
isotretinoin	Capsule, soft	10 mg	Current	Limited Availability	Manufacturing	28/03/2025
neostigmine methylsulfate	Injection, solution	2.5 mg	Current	Unavailable	Manufacturing	28/03/2025
simvastatin	Tablet, film coated	80 mg	Current	Unavailable	Manufacturing	28/03/2025
linezolid	Tablet, film coated	600 mg	Current	Limited Availability	Manufacturing	28/03/2025
ezetimibe	Tablet, uncoated	10 mg	Current	Unavailable	Manufacturing	28/03/2025
anastrozole	Tablet, film coated	1 mg	Current	Limited Availability	Manufacturing	28/03/2025
acamprosate calcium	Tablet, enteric coated	333 mg	Current	Limited Availability	Manufacturing	28/03/2025
dosulepin (dothiepin) hydrochloride	Capsule, hard	25 mg	Current	Limited Availability	Manufacturing	28/03/2025
sodium nitroprusside	Injection, concentrated	50 mg	Anticipated	Available	Commercial Changes / Commercial viability	28/03/2025
fentanyl citrate~ropivacaine hydrochloride	Injection, solution	3.14 microgram/mL~2 mg/mL	Discontinued	Reduction in supply until supply is exhausted	Commercial Changes / Commercial viability	28/03/2025
fentanyl citrate~ropivacaine hydrochloride	Injection, solution	3.14 microgram/mL~2 mg/mL	Discontinued	Unavailable	Commercial Changes / Commercial viability	28/03/2025
ropivacaine hydrochloride~fentanyl citrate	Injection, solution	2 mg/mL~6.28 microgram/mL	Discontinued	Unavailable	Commercial Changes / Commercial viability	28/03/2025
ropivacaine hydrochloride~fentanyl citrate	Injection, solution	2 mg/mL~6.28 microgram/mL	Discontinued	Unavailable	Commercial Changes / Commercial viability	28/03/2025
metformin hydrochloride	Tablet, film coated	1000 mg	Anticipated	Available	Unexpected increase in demand due to other sponsors unable to supply	28/03/2025
gabapentin	Capsule, hard	300 mg	Current	Limited Availability	Manufacturing	27/03/2025
adrenaline (epinephrine) acid tartrate~lidocaine hydrochloride monohydrate	Injection, solution	22.7 microgram/mL~21.3 mg/mL	Current	Limited Availability	Manufacturing	27/03/2025
sumatriptan succinate	Tablet, film coated	140 mg	Current	Unavailable	Manufacturing	27/03/2025
venlafaxine	Capsule, modified release	75 mg	Current	Limited Availability	Manufacturing	27/03/2025
clomipramine hydrochloride	Tablet, film coated	25 mg	Current	Limited Availability	Manufacturing	27/03/2025
mycophenolate mofetil	Tablet, film coated	500 mg	Current	Unavailable	Manufacturing	27/03/2025
clopidogrel hydrogen sulfate	Tablet, film coated	97.9 mg	Current	Limited Availability	Unexpected increase in consumer demand	27/03/2025
risperidone	Tablet, film coated	1 mg	Current	Unavailable	Unexpected increase in consumer demand	27/03/2025
metformin hydrochloride	Tablet, film coated	1000 mg	Current	Unavailable	Manufacturing	27/03/2025
capecitabine	Tablet, film coated	500 mg	Current	Limited Availability	Unexpected increase in consumer demand	27/03/2025
entecavir	Tablet, film coated	.5 mg	Current	Unavailable	Manufacturing	27/03/2025
prilocaine hydrochloride~felypressin	Injection, solution	30 mg/mL~.54 microgram/mL	Current	Unavailable	Manufacturing	27/03/2025
dexmedetomidine hydrochloride	Injection, concentrated	118 microgram/mL	Current	Unavailable	Manufacturing	27/03/2025
emtricitabine~efavirenz~tenofovir disoproxil maleate	Tablet, film coated	200 mg~600 mg~300 mg	Current	Limited Availability	Manufacturing	27/03/2025
atorvastatin calcium trihydrate	Tablet, film coated	43.376 mg	Current	Unavailable	Manufacturing	27/03/2025
naproxen	Tablet	500 mg	Current	Unavailable	Manufacturing	27/03/2025
metformin hydrochloride	Tablet, film coated	850 mg	Current	Unavailable	Manufacturing	27/03/2025
metformin hydrochloride	Tablet, film coated	1000 mg	Current	Unavailable	Manufacturing	27/03/2025
letrozole	Tablet, film coated	2.5 mg	Current	Unavailable	Manufacturing	26/03/2025
fluorouracil	Injection, solution	5000 mg	Current	Unavailable	Unexpected increase in consumer demand	26/03/2025
pramipexole dihydrochloride monohydrate	Tablet	.125 mg	Current	Unavailable	Manufacturing	26/03/2025
clonidine hydrochloride	Tablet, uncoated	100 microgram	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	26/03/2025
atorvastatin calcium trihydrate~amlodipine besilate	Tablet, film coated	21.688 mg~13.88 mg	Current	Limited Availability	Manufacturing	26/03/2025
rosuvastatin calcium~ezetimibe	Tablet~Tablet, film coated	41.583 mg~10 mg	Anticipated	Available	Manufacturing	26/03/2025
rosuvastatin calcium~ezetimibe	Tablet~Tablet, film coated	10.396 mg~10 mg	Current	Unavailable	Manufacturing	26/03/2025
ezetimibe~rosuvastatin calcium	Tablet~Tablet, film coated	10 mg~20.791 mg	Resolved	Available	Manufacturing	26/03/2025
pramipexole dihydrochloride monohydrate	Tablet	.125 mg	Current	Limited Availability	Unexpected increase in consumer demand	26/03/2025
oxycodone hydrochloride	Capsule, hard	10 mg	Current	Unavailable	Commercial Changes / Commercial viability	26/03/2025
oxycodone hydrochloride	Capsule, hard	20 mg	Current	Unavailable	Commercial Changes / Commercial viability	26/03/2025
emtricitabine~tenofovir disoproxil fumarate	Tablet, film coated	200 mg~300 mg	Resolved	Available	Manufacturing	26/03/2025
Pegfilgrastim	Injection, solution	6 mg	Anticipated	Available	Manufacturing	26/03/2025
emtricitabine~tenofovir disoproxil fumarate	Tablet, film coated	200 mg~300 mg	Current	Limited Availability	Manufacturing	26/03/2025
melatonin	Oral Liquid, solution	1 mg/mL	Resolved	Available	Unexpected increase in consumer demand	26/03/2025
gentamicin sulfate	Injection, solution	135.6 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	26/03/2025
ethinylestradiol~norethisterone	Tablet, uncoated	36 microgram~500 microgram	Current	Unavailable	Unexpected increase in consumer demand	26/03/2025
iopromide	Injection, solution	498.72 mg/mL	Current	Unavailable	Manufacturing	26/03/2025
clonidine hydrochloride	Tablet, uncoated	150 microgram	Resolved	Available	Transport / Logistic issues / Storage capacity issues	26/03/2025
zoledronic acid	Injection, concentrated	4 mg	Resolved	Available	Commercial Changes / Commercial viability	26/03/2025
nizatidine	Capsule	150 mg	Current	Limited Availability	Manufacturing	26/03/2025
isosorbide dinitrate	Tablet, uncoated	5 mg	Anticipated	Available	Manufacturing	25/03/2025
trihexyphenidyl (benzhexol) hydrochloride	Tablet, uncoated	5 mg	Current	Limited Availability	Unexpected increase in consumer demand	25/03/2025
venlafaxine hydrochloride	Capsule, modified release	169.71 mg	Current	Unavailable	Unexpected increase in demand due to other sponsors unable to supply	25/03/2025
venlafaxine hydrochloride	Capsule, modified release	84.86 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	25/03/2025
mycophenolate mofetil	Capsule	250 mg	Anticipated	Available	Manufacturing	25/03/2025
galantamine hydrobromide	Capsule, modified release	30.756 mg	Anticipated	Available	Manufacturing	25/03/2025
ondansetron	Tablet, orally disintegrating	8 mg	Current	Limited Availability	Manufacturing	25/03/2025
quetiapine fumarate	Tablet, modified release	57.565 mg	Anticipated	Available	Unexpected increase in consumer demand	25/03/2025
ketorolac trometamol	Injection, solution	30 mg/mL	Anticipated	Available	Commercial Changes / Commercial viability	25/03/2025
pemetrexed disodium	Injection, powder for	1102.9 mg	Current	Limited Availability	Manufacturing	25/03/2025
tobramycin	Injection, solution	40 mg/mL	Resolved	Available	Unexpected increase in consumer demand	25/03/2025
fluorouracil	Injection, solution	50 mg/mL	Current	Unavailable	Manufacturing	25/03/2025
hydrocortisone	Tablet, uncoated	4 mg	Anticipated	Available	Manufacturing	25/03/2025
olanzapine	Tablet, uncoated	5 mg	Current	Unavailable	Manufacturing	25/03/2025
thiotepa	Injection, powder for	15 mg	Current	Unavailable	Commercial Changes / Commercial viability	25/03/2025
thiotepa	Injection, powder for	100 mg	Current	Unavailable	Commercial Changes / Commercial viability	25/03/2025
thiotepa	Injection, powder for	400 mg	Current	Unavailable	Commercial Changes / Commercial viability	25/03/2025
clopidogrel hydrogen sulfate	Tablet, film coated	97.875 mg	Current	Unavailable	Manufacturing	25/03/2025
lorazepam	Tablet	2.5 mg	Current	Unavailable	Manufacturing	25/03/2025
cisatracurium besilate	Injection, solution	13.4 mg	Resolved	Available	Manufacturing	25/03/2025
spironolactone	Tablet, film coated	100 mg	Anticipated	Available	Manufacturing	25/03/2025
hydroxocobalamin chloride	Injection, solution	1 mg/mL	Current	Unavailable	Manufacturing	24/03/2025
metoprolol succinate	Tablet, modified release	47.5 mg	Resolved	Available	Manufacturing	24/03/2025
metoprolol succinate	Tablet, modified release	190 mg	Resolved	Available	Manufacturing	24/03/2025
metoprolol succinate	Tablet, modified release	95 mg	Resolved	Available	Manufacturing	24/03/2025
trandolapril	Capsule, hard	1 mg	Current	Unavailable	Manufacturing	24/03/2025
trandolapril	Capsule, hard	4 mg	Current	Unavailable	Manufacturing	24/03/2025
quetiapine fumarate	Tablet, modified release	172.695 mg	Anticipated	Available	Unexpected increase in consumer demand	24/03/2025
quetiapine fumarate	Tablet, modified release	57.565 mg	Anticipated	Available	Unexpected increase in consumer demand	24/03/2025
methotrexate	Injection, solution	100 mg/mL	Current	Unavailable	Manufacturing	24/03/2025
citalopram hydrobromide	Tablet, film coated	49.98 mg	Resolved	Available	Manufacturing	24/03/2025
metformin hydrochloride	Tablet, film coated	500 mg	Current	Limited Availability	Unexpected increase in demand due to other sponsors unable to supply	24/03/2025
deferasirox	Tablet, film coated	90 mg	Anticipated	Available	Manufacturing	24/03/2025
atorvastatin calcium trihydrate	Tablet, film coated	21.688 mg	Current	Limited Availability	Manufacturing	24/03/2025
ethanol absolute~carmustine	Diluent, not applicable~Injection, powder for	3 mL~100 mg	Current	Unavailable	Unexpected increase in demand due to other sponsors unable to supply	24/03/2025
deferasirox	Tablet, film coated	360 mg	Current	Unavailable	Manufacturing	24/03/2025
metoclopramide hydrochloride monohydrate	Injection, solution	10.54 mg	Anticipated	Available	Unexpected increase in consumer demand	24/03/2025
permethrin	Cream	50 mg/g	Current	Limited Availability	Commercial Changes / Commercial viability	24/03/2025
dydrogesterone~estradiol	Tablet, film coated	10 mg~2 mg	Current	Unavailable	Manufacturing	24/03/2025

2025.03.30 [ 米国 ]

ASHP供給不足情報（2025年3月24日～3月30日）

Generic Name	Shortage Status	Revision Date
Rifapentine Tablets	Current Shortages	28-Mar-25
Mercaptopurine Tablets	Current Shortages	27-Mar-25
Rifaximin Tablets	Current Shortages	27-Mar-25
Cefotaxime Sodium Injection	Current Shortages	26-Mar-25
Dihydroergotamine Mesylate Injection	Current Shortages	25-Mar-25
Doxorubicin Injection	Current Shortages	25-Mar-25
Insulin Degludec Injection	Current Shortages	25-Mar-25
Levofloxacin Injection in 5% Dextrose	Current Shortages	25-Mar-25
Liraglutide Injection	Current Shortages	25-Mar-25
Meperidine Hydrochloride Injection	Current Shortages	25-Mar-25
Mitomycin Injection	Current Shortages	25-Mar-25
Pantoprazole Injection	Current Shortages	25-Mar-25
Phentolamine Mesylate for Injection	Current Shortages	25-Mar-25
Pimecrolimus 1% Topical Cream	Current Shortages	25-Mar-25
Sodium Acetate Injection	Current Shortages	25-Mar-25
Desiccated Thyroid Tablets	Current Shortages	24-Mar-25
Dorzolamide Ophthalmic Solution	Current Shortages	24-Mar-25
Doxorubicin Liposomal Injection	Current Shortages	24-Mar-25
Dulaglutide Injection	Current Shortages	24-Mar-25
Fentanyl Citrate Injection	Current Shortages	24-Mar-25
Heparin Sodium Premixed Bags	Current Shortages	24-Mar-25
Hydromorphone Hydrochloride Injection	Current Shortages	24-Mar-25
Indocyanine Green	Current Shortages	24-Mar-25
Ketamine Injection	Current Shortages	24-Mar-25
Midazolam Injection	Current Shortages	24-Mar-25
Nafcillin Sodium Injection	Current Shortages	24-Mar-25
Nitrofurantoin Oral Suspension	Current Shortages	24-Mar-25
Sodium Ferric Gluconate Complex	Current Shortages	24-Mar-25